【病毒外文文獻】2009 ChemInform Abstract_ Design and Synthesis of Cinanserin Analogues as Severe Acute Respiratory Syndrome Coronavirus
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www cheminform wiley vch de Thioethers Q 0580 Design and Synthesis of Cinanserin Analogues as Severe Acute Respiratory Syn drome Coronavirus 3CL Protease Inhibitors Cinanserin analogs 26 examples are synthesized and tested for their inhibitory activities against SARS coronavirus 3CL protease Four derivatives show significant activities Derivative If the most potent compound is 300 fold more potent than cinanserin Ia itself YANG Q CHEN L HE X GAO Z SHEN X BAI D Chem Pharm Bull 56 2008 10 1400 1405 Shanghai Inst Mater Med Chin Acad Sci Shanghai 201203 Peop Rep China Eng H Toeppel 13 079 ChemInform 2009 40 issue 13 2009 Wiley VCH Verlag GmbH Co KGaA Weinheim- 配套講稿:
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